Numerical Investigation of the Performance of Coulter Counter with Novel Structure
Keywords:
micro coulter counter, particle counting, resistance change, size effect.Abstract
Coulter counters are instruments designed to count particles of various shapes and sizes. A significant limitation of the contemporary coulter device is high throughput. In this article, a novel coulter structure is proposed and the change of resistance due to particle
translocation is studied numerically. The simulation results show the resistance change affected by the cell size as well as the cell location. The cases when cells stick together and nonstick to translocate in the channel are also analyzed numerically. A coulter device with multiple sensing units is modeled and simulated to investigate the effect of cross-talk between sensing channels. The studies provide useful instructions for the design of solid-state vertical micro Coulter counter for high throughput particles counting and scaling up for a counter array.
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